Simone performs with eminent conductors such as Jaap van Zweden, Antonio Pappano, Paavo Järvi, Gianandrea Noseda, Tarmo Peltokoski, Yannick Nézet-Séguin, Vladimir Jurowski, Rafael Payare, Louis Langrée, Gustavo Gimeno, Karina Canellakis, Jonathon Heyward, Stanislav Kochanovsky, Kazuki Yamada, Marc Albrecht, Stéphane Denève, Vassily Petrenko, Domingo Hindoyan, Michael Francis, Simone Young, François-Xavier Roth, Olari Elts, Fabien Gabel, Duncan Ward, Juraj Valcuha, John Storgards, Omer Meir-Wellber, Edward Gardner, Kent Nagano, Jukka-Pekka Saraste, James Gaffigan, Sir Mark Elder, Daniel Raiskin, Edo de Waart, Andris Poga, Jun Märkl, Kevin John Edusei, Markus Stenz, Antony Hermus, Jaime Martin, Case Scaglione, Alexander Shelley, Jader Bignamini, Mark Wigglesworth, Asher Fisch and Petr Popelka.

In the 2025/26 season, Simone will return, among several engagements, to the Orchestre Symphonique de Montréal with Rafael Payare, Seoul Philharmonic with Jaap van Zweden, Rotterdam Philharmonic with Tarmo Peltokoski, Sydney Symphony with Simone Young, RAI Symphony with Alpesh Chauhan, Baltimore Symphony with Jonathon Heyward, Antwerp Symphony at the Enescu Festival with Emmanuel Tjeknavorian, BBC Philharmonic with John Storgards, Liverpool Philharmonic with Domingo Hindoyan and debut with Singapore Symphony under Hannu Lintu, Seattle Symphony Orchestra under Sunny Xia and Orchestra della Svizzera Italiana under Pierre Bleuse. She will also play recitals with pianist Jonathan Fournel at the Concertgebouw Amsterdam, Wigmore Hall and Heidelberger Frühling Festival. In 2025 Simone premiered a work by leading Dutch composer Joey Roukens at the Tivoli Vredenbrug Utrecht and a piece by Danish composer Thomas Agerfeldt Olesen co-commissioned by the Danish National Symphony and Vancouver Symphony Orchestras. 

In 2022 her most recent recording was released to great acclaim, featuring late works by Rautavaara, including a world première, with the Malmö Symphony and Robert Trevino for the Ondine label. Other recordings include Shostakovich’s first Violin Concerto and Gubaidulina’s In Tempus praesens with the Netherlands Radio Philharmonic under James Gaffigan and Reinbert de Leeuw on Challenge Classics, and a recital album of works by Mendelssohn, Janáček and Schumann with pianist Robert Kulek, also on Challenge Classics.

In 2019, Simone was made a Fellow of the Royal Academy of Music in London, an honour limited to 300 former Academy students, and awarded to those musicians who have distinguished themselves within the profession.

Simone Lamsma plays the 1703 ​‘Aurora ex-Foulis’ Stradivarius, on generous loan to her by a benefactor.